氫氣人體安全性是氫氣醫(yī)學最重要的特點。氫氣安全性最重要的證據來自潛水醫(yī)學，具體就是關于氫氣人體和動物潛水研究。
 

潛水技術中氫氣使用的壓力非常高，或者說劑量極大，研究中除了發(fā)現存在一些生理功能影響外，這些影響部分是因為高壓產生的效應，沒有發(fā)現氫氣有任何毒性效應，這是氫氣可應用于潛水的前提條件。
 

任何用于潛水的氣體都必須沒有毒性。潛水中使用氫氣需要非常時間連續(xù)暴露，例如需要幾周時間，高壓意味著需要非常高的劑量，這樣的暴露條件要求任何氣體必須對人體沒有絲毫毒性。能用于潛水的氣體包括空氣、氦氣、氮氣、氫氣，大深度情況則只能用氦氣和氫氣，因為高壓空氣和氮氣會有毒性。所以說氫氣和氦氣的人體安全性比空氣和氮氣都高。
 

整理一下氫氣潛水的有關文獻，對從事氫氣醫(yī)學研究的學者和產業(yè)都非常重要，昨天恰好有同行來請教這方面的信息，我花費了一個上午整理了這個目錄，希望對大家有幫助。
 

部分重要的文獻，我閱讀后選擇給大家重點介紹。如有全文需要，可留言。
 

新冠疫情面前，一定要服從大局，少出門，靜候佳音!
 

l Ball, Robert. (2001). Biochemical decompressionof hydrogen by naturally occurring bacterial flora in pigs: What are theimplications for human hydrogen diving?. Undersea & hyperbaric medicine :journal of the Undersea and Hyperbaric Medical Society, Inc. 28. 55-6.用細菌分解氫氣進行潛水減壓。

l Fahlman A. On the Physiology of Hydrogen Divingand Its Implication for Hydrogen Biochemical Decompression[D]. Carleton University,Ottawa, ON, Canada., 2000.氫氣潛水生理學和生物減壓技術

l Rostain J C, Gardette-Chauffour M C, GardetteB. Hydrogen, a gas for diving: a mini review[J]. Undersea and Hyperbaric Med, 1999,26: 62. 氫氣潛水小綜述

l Kayar S R, Parker E C. Oxygen pulse in guineapigs in hyperbaric helium and hydrogen[J]. Journal of Applied Physiology, 1997,82(3): 988-997.氫氣潛水動物實驗

l Lillo R S, Parker E C, Porter W R.Decompression comparison of helium and hydrogen in rats[J]. Journal of AppliedPhysiology, 1997, 82(3): 892-901.大鼠氫氣和氦氣潛水減壓的比較

l Abraini J H, Martinez E, Lemaire C, et al.ANXIETY, SENSORIMOTOR AND COGNITIVE PERFORMANCE DURING A HYDROGEN–OXYGEN DIVEAND LONG-TERM CONFINEMENT IN A PRESSURE CHAMBER[J]. Journal of environmentalpsychology, 1997, 17(2): 157-164.(氫氧長期高壓暴露對人體的副作用)

l Gardette B, Gortan C, Delauze H G. Heliumin-hydrogen out. A new diving technique[C]//Proceedings of the 23rd AnnualScientific Meeting of the European Underwater and Baromedical Society, Bled(Slovenia). 1997. 這是介紹氫氣在潛水中的實用技術，就是如何在實用中使用氫氣代替氦氣，推薦重點閱讀。

l Abraini J H, Gardette-Chauffour M C, MartinezE, et al. Psychophysiological reactions in humans during an open sea dive to500 m with a hydrogen-helium-oxygen mixture[J]. Journal of Applied Physiology,1994, 76(3): 1113-1118.氫氦氧潛水500米(50個大氣壓)潛水的心理反應。

l Gardette B, Massimelli J Y, Comet M, et al.DEEP HYDROGEN DIVING: HYDRA 10-A 701 MSW RECORD DIVE[J]. 1993.人類最大潛水深度記錄700米，是使用的氫氣潛水

l Segadal K, Gulsvik A, Nicolaysen G. Respiratorychanges with deep diving[J]. European Respiratory Journal, 1990, 3(1): 101-108.深潛呼吸效應，包含氫氣潛水

l Imbert G, Ciesielski T, Fructus X. Safe deepsea diving using hydrogen[J]. Marine Technology Society journal, 1989, 23(4):26-33.使用氫氣的安全潛水深度

l Puckett J H, Bartholomew A P. DIVING AT 520M ONHYDROGEN-HELIUM-OXYGEN MIXED GAS FROM DYNAMICALLY POSITIONED DIVING SUPPORTVESSEL ORELIA[J]. 1989.520米氫氦氧潛水

l Gardette B. Compression procedures for mice andhuman hydrogen deep diving COMEX HYDRA program[J]. High pressure nervoussyndrome, 1989, 20: 217-231.人類和小鼠氫潛水項目介紹，高壓神經綜合征角度

l Ciesielski T, Imbert J P. Hydrogen offshorediving to a depth of 530 m: hydra VIII[C]//Offshore Technology Conference.Offshore Technology Conference, 1989.530米氫氣海上潛水試驗

l Rostain, Jean-Claude & Gardette-Chauffour,M & Lemaire, C & Naquet, R. (1988). Effects of a H2-He-O2 mixture onthe HPNS up to 450 msw. Undersea biomedical research. 15. 257-70.450米深度氫氣潛水

l Imbert, J. & Gortan, C. & Fructus, X.& Ciesielski, T. & Gardette, B.. (1987). Hydra 8: Pre-commercialHydrogen Diving Project. 14. 10.1007/978-94-009-1299-1_13.商業(yè)氫氣潛水項目介紹

l Gortan C, Delauze H G. Hydra V HydrogenExperimental Dive To 450 Meters[C]//Offshore technology conference. OffshoreTechnology Conference, 1986.氫氣試驗潛水會議論文

l Edel P. Evaluation of the Use ofHydrogen-Oxygen as a Breathing Gas in Deep-Sea Diving[R]. SEA-SPACE RESEARCH COINC MARRERO LA, 1986.氫氣作為潛水氣體

l Hills B A. Hydrogen-oxygen mixer apparatus andprocess: U.S. Patent 4,269,791[P]. 1981-5-26.美國氫氧混合技術專利

l Gardette B, Comet M, Gortan C, et al. Life in aHyperbaric Environment: A New O 2-H 2 Breathing Mixture for IndustrialDiving[J]. 1988.

l Brauer R W. Hydrogen as a Diving Gas[J]. 1985.

l Fife W. The use of non-explosive mixtures ofhydrogen and oxygen for diving[J]. 1979.

l Dougherty J J H. Use of H2 as an inert gasduring diving: pulmonary function during H2-O2 breathing at 7.06 ATA[J].Aviation, space, and environmental medicine, 1976,47(6): 618-626.7個大氣壓氫氣潛水對呼吸功能的影響

l Dougherty J H. The Use of Hydrogen as an InertGas During Diving: Pulmonary Functions During Hydrogen-oxygen Breathing atPressures Equivalent to 200 Feet of Sea Water[M]. Naval Submarine MedicalResearch Laboratory, Bureau of Medicine and Surgery, Navy Department, 1974.氫氣潛水呼吸系統(tǒng)研究

l Edmonds C, Lowry C, Pennefather J. History ofdiving[J]. 1975.潛水歷史其中有關于氫氣潛水的早期歷史介紹

l Edel P O, Holland J M, Fischer C L, et al.Preliminary studies of hydrogen-oxygen breathing mixtures for deep seadiving[J]. Proc Oceanology International. London: Society for UnderwaterTechnology, 1972: 485-489.氫氧潛水的早期研究

l Nuckols M L, Van Zandt K, Finlayson W S, et al.Hot water heater for diver using hydrogen catalytic reactions: U.S. Patent6,463,925[P]. 2002-10-15.(用氫氣給潛水員加熱)

l Albert D. Combined diving device andelectrolysis operated oxygen generator: U.S. Patent 3,504,669[P]. 1970-4-7.電解水供氧潛水裝置

l Welhan J A, Craig H. Methane, hydrogen andhelium in hydrothermal fluids at 21 N on the East Pacific Rise[M]//Hydrothermalprocesses at seafloor spreading centers. Springer, Boston, MA, 1983:391-409. 東太平洋海底氫氣

l Holmstedt G S. The upper limit of flammabilityof hydrogen in air, oxygen, and oxygen-inert mixtures at elevated pressures[J].Combustion and Flame, 1971, 17(3): 295-301.氫氣可燃性規(guī)律的早期研究